This edition of our journal begins in the obstetrics section with a paper about the metabolic model for the monitoring and management of gestational diabetes, based on a descriptive, retrospective and observational study.

The prenatal diagnosis of chromosomal anomalies is of high importance in cases of pregnancies with an increased risk, such as the mother’s age over 35 years old, abnormal results of biochemical screening tests, fetal malforma­tions, deficient development, other pregnancies or children with chromosomal anomalies or genetic mutations, dead fetuses, and with other pathological conditions. Thus, the study presented in the next paper underlines the utility of the QF-PCR analysis for the prenatal diagnosis of aneuploidies and the importance of karyotype which remains the best solution for the final decision regarding the pregnancy.

The last decades have witnessed the rise of reproductive medicine to the status of a significant branch of medicine. In response to these challenges, a new series of investigations have been tested and approved, laying the foundation for a different approach to infertility. Therefore, the next article aims at reviewing the data from literature, highlighting the relevance of the recent investigations in reproductive medicine and conferring a framework for them.

Moving on to the gynecology section, breast cancer is a complex disease that can be caused by a combination of genetic and environmental factors. Several genes have been identified to be associated with an increased risk of breast cancer. These genes can be tested for mutations in order to assess an individual’s risk of developing breast cancer. Immunohistochemistry plays a significant role in personalized breast cancer treatment by providing information on the specific proteins and biomarkers present in a patient’s tumor.

According to the International Fede­ra­tion of Gynecology and Obstetrics (FIGO), cervical cancer staging is rea­lized through clinical examination. The imaging and the subsequent surgical findings come in addition to the first staging. Although in incipient stages surgery is the first step in the treatment, in advanced stages the treatment op­tions are based on the clinical staging in corroboration with imaging techniques. Thus, in the following paper, it is presented a retrospective study that included patients with cervical cancer for which imaging evaluation of the lymph nodes was performed, being compared with post-surgery histopathological results.

The next paper presents the case of a 26-year-old nulligravida with OHVIRA syndrome, previously operated for rudimentary horn excision, diagnosed with vaginal pseudocyst.

In the end, it is our great pleasure to invite all of you to the National Congress of Fetal and Neonatal Medicine which will take place between 11 and 13 May 2023, at Ramada Plaza Hotel, Bucharest.

Last but not least, the editorial team would like to wish all the readers a Happy Easter! Warmest wishes from our family to yours on this holy day!