Vol. 67 – No. 4/2018
The role of biomarkers in the management of non-small cell lung cancer
Lung cancer is an important public health problem, and worldwide it became the leading cause of cancer-related death in both men and women; the survival rate at 5 years after diagnosis is about 18%. The predominant histological type (85%) is non-small cell lung cancer - adenocarcinoma, squamous cell carcinoma, and large cell carcinoma; due to the lack of symptoms in most cases it is diagnosed late, and the patients cannot benefit of a curative treatment. Lack of a sustained response to standard chemotherapy and poor prognosis of patients in advanced stages of the disease, with metastases, led to the intensive studies of the molecular profile of this cancer type in order to develop innovative targeted therapies with a favorable impact on prognosis.
Miron A. Bogdan
20 decembrie 2018