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Introduction

Iron deficiency anemia is a real public health problem for all ages. Its importance is given by the fact that it can occur in pregnancy, with consequences for the newborn and infant, but which can later be carried over to older ages.

It is well known that a variety of lifestyle factors can have negative effects on pregnancy, and some may be teratogenic⁽¹⁾. Maternal hemoglobin below 8 g/dl has been associated with a 2.7-fold increase in the risk of preterm birth and with a 3.1-fold increase in low birth weight due to increased prematurity and intrauterine growth retardation^(2,3). Severe anemia is associated with an increased risk of motor and cognitive impairments, reduced amniotic fluid volume, fetal cerebral vasodilation and fetal death^(2,4,5), and with death in approximately 30% of infants hospitalized with anemia without immediate blood transfusion⁽⁶⁾. Perinatal mortality rates increase significantly when maternal Hb values are below 11 g/dL, increase 2-3-fold at values below 8 g/dL and 8-10-fold at values below 5 g/dL⁽⁷⁾. Newborns of anemic and nonanemic mothers did not show significant differences in hematological values obtained from cord blood. However, at 3 months of age, serum ferritin levels were significantly higher in infants of non-anemic mothers, and also the anthropometric parameters were normal. Significantly decreased immune response, growth retardation, impaired tooth integrity and salivary gland dysfunction can occur in prenatally iron-deficient infants^(6,8).

Iron supplementation during pregnancy positively influences APGAR score and fetal Hb level for three months after birth⁽⁷⁾. Positive response to iron supplementation is when Hb>10.5 g/dl, ferritin is above 12 µg/ml or transferrin saturation is above 16%⁽¹⁰⁾, but compliance with iron supplementation in pregnancy is generally low, with only 49.7% of pregnant women consistently taking supplements in the second and third trimesters of pregnancy⁽¹¹⁾. High doses of iron supplements, often up to 300 mg/day of ferrous iron, are usually prescribed for the treatment of iron deficiency anemia, but studies have shown that high doses may increase the risk of low gestational age weight of the fetus in the first and second trimesters⁽¹²⁾.

One study has shown that depletion of iron stores without symptoms of anemia in early pregnancy poses a high risk of decreased fetal weight, even with moderate daily intake of iron supplements, and that optimal fetal birth weight is achieved when nonsmoking women enter pregnancy with BMI between 22 and 26 kg/m², are not anemic, have iron store levels above 300 mg (reflected by serum ferritin levels above 30 µg/l) and receive moderate doses of prenatal iron supplementation during pregnancy, so that Hb values are maintained between 95 and 125 g/l⁽¹³⁾.

The objective of the present research was to assess the consequences of anemia in pregnancy on the newborn, in order to draw conclusions with clinical applicability in practice.

Materials and method

This observational study was conducted on a group of pregnant women (N=54) admitted to the maternity ward of the “Sf. Ioan cel Nou” Emergency County Hospital in Suceava, Romania, between March and May 2017, a short but significant interval for the scientific approach. The study followed the principles outlined in the Declaration of Helsinki. After obtaining the agreement from the hospital scientific committee and the informed consent from the pregnant women, the interviewer completed a questionnaire in which general data from the Pregnant Women’s Notebook⁽¹⁴⁾ were used, including some important for our study: gestational age, hemoglobin and hematocrit values, type of delivery, birth weight of the newborn, APGAR score, presence of neonatal pathologies and duration of hospitalization.

The database containing the pregnant women’s responses to the questionnaire was processed using specialized software (Microsoft Excel, Statistica 8.0, Medcalc 13.3.3, SPSS 18.0). The results were interpreted and processed graphically, after which the conclusions of the study were formulated.

Results

The age of mothers from our study ranged from 16 to 46 years old (mean age = 30). Gestational age ranged from 28 to 40 weeks, with a mean of 39 weeks. Of the total number of newborns, 26% were preterm (gestational age < 37 weeks).

Regarding the assessment of anemia in pregnant women in the study group, hemoglobin values ranged from 7.7 to 14.5 g/dl (Figure 1). A percentage of 48% of the pregnant women had mild (Hb=9-11.5 g/dl) or moderate (Hb<9 g/dl) forms of anemia during pregnancy.
 

Hematocrit values ranged from 24% to 42% (Figure 2), which correlated statistically significantly with hemoglobin values (p<0.0001) – Figure 3.
 

In the study group, there were 16 cases of premature births (30%) and 38 term births (70%). A correlation between hemoglobin value and gestational age was performed to see if there was a causal relationship. However, the nonparametric test did not test the hypothesis (p=0.155). Figure 4 shows that hemoglobin values are at approximately the same level in both groups.
 

Neither was newborn weight significantly influenced by maternal hemoglobin level (p=0.353), even though it varied between 1360 g and 4510 g (mean weight = 3020 g) – Figure 5.
 

Although there are studies showing that the risk of preterm birth and lower birth weight are among the common consequences of iron deficiency anemia in pregnancy⁽⁷⁾, the results of our study did not confirm this causal relationship.

The APGAR score at birth ranged from 5 to 10 (mean APGAR = 9), indicating that generally the newborns had a favorable adaptation to extrauterine life and a good immediate prognosis (Figure 6).
 

In contrast, in correlation with the hemoglobin values found in the patients in the study group, the lower APGAR score meant a more difficult neonatal adaptation to extrauterine life in the newborns of pregnant women with anemia (p=0.024) – Figure 7. Thus, there was a positive correlation between anemia in pregnancy and the lower APGAR score at birth.
 

In our approach to study the influences of anemia in pregnant women on the infant, the statistical result showed that anemia during pregnancy did not influence the mother’s ability to breastfeed (p=0.333) – Figure 8. 
 

Regarding the occurrence of various pathological conditions in the neonatal period, these were most frequently represented by prolonged neonatal jaundice (26%; N=16), neonatal anemia (15%; N=8) and neonatal respiratory distress syndrome (11%; N=6). Also, 56% of the neonates (N=24) had no particular neonatal pathology (Figure 9).
 

The statistical correlation between maternal hemoglobin value and the occurrence of perinatal pathologies in the newborn, some of them of significant severity, was significant (p<0.0009) – Figure 10, but anemia during pregnancy was a risk factor for the occurrence of neonatal pathologies in 56% of newborns (N=30).
 

Studies have shown that iron supplementation during pregnancy improves average fetal weight (by 6.46 g/month, along with folic acid)⁽⁹⁾. The results of our study confirm these data (p=0.048).

Conclusions

Given the results of the study, we provided major findings regarding iron deficiency anemia in pregnant women in relation to gestational age, birth weight, APGAR score and the presence of neonatal pathologies. Although the prevalence of iron deficiency anemia in pregnant women was quite high in the study group, low hemoglobin values during pregnancy did not significantly influence the gestational age and newborn weight, but they were significantly correlated with difficult adaptation to extrauterine life (APGAR score) and with newborn pathologies (prolonged jaundice, anemia, respiratory distress). At the same time, preterm infants required prolonged hospitalization to receive adapted artificial feeding, being deprived of the benefits of natural feeding. Thus, we consider that prophylaxis of iron deficiency anemia in pregnant women remains of major practical importance, with a positive impact also on the newborn.  

Acknowledgements. This article contains the results of a study carried out for a dissertation. The authors thank all the women who participated in the study, as well as the authorities of the “Sf. Ioan cel Nou” County Emergency Clinical Hospital, Suceava, for their cooperation in the research.

Authors’ contribution

O.A. – study design, data interpretation, critical revision and editing of manuscript, final approval for publication.

P.M. – study design, research implementation, drafting of manuscript, data collection, statistical analysis, data interpretation, final approval for publication.

B.S. – study design, study validation and supervision, critical review of manuscript, final approval for publication.

Conflict of interests: The authors declare no con­flict of interests.